Table 2 MIC of P2 for chaperone deletion strains
From: Aggregating sequences that occur in many proteins constitute weak spots of bacterial proteostasis
Gene deletion | MIC (μg/mL) | Protein name | Description |
|---|---|---|---|
KEIO WT | 12 | ||
∆ clpP | 12 | ClpP | Proteolytic subunit of the Clp protease |
∆ clpA | 12 | ClpA | Substrate-specifying adapter for the Clp protease |
∆ clpS | 12 | ClpS | Specificity adapter for the Clp protease (binds to and modulates ClpA) |
∆ clpX | 12 | ClpX | ATP-binding subunit of the Clp protease |
∆ lon | 12 | Lon | ATP-dependent protease, required for suppression of aggregation |
∆ sulA | 12 | SulA | Suppressor of Lon |
∆ clpB | 12 | ClpB | Disaggregase of the Hsp100 family |
∆ dnaK | 6 | DnaK | Folding chaperone of the Hsp70 family |
∆ dnaJ | 12 | DnaJ | Cochaperone to DnaK of the Hsp40 family |
∆ grpE | n/a | GrpE | Nucleotide exchange factor for DnaK |
∆ htpG | 12 | Folding chaperone of the Hsp90 family | |
∆ groL | 12 | GroEL | Folding chaperone of the Hsp60 family |
∆ groS | n/a | GroES | Cochaperone of Hsp60, of the Hsp10 family |
∆ hslO | 12 | Hsp33 | Oxidative stress-induced holdase |
∆ hchA | 6 | Hsp31 | Heat-dependent and temperature-stress-dependent holdase |
∆ ibpA | 12 | IbpA | Small Hsp of the α-crystallin family |
∆ ibpB | 12 | ibpB | Small Hsp of the α-crystallin family |
∆ tig | 12 | Trigger factor | Cotranslational folding chaperone, ribosome-associated |
