Fig. 4
Lactobacillus rhamnosus (LGG)-associated fecal products promote Treg cell expansion and IL10 production ex vivo at 6 months of age. Sterile fecal water derived from 6-month-old LGG-supplemented high risk for asthma (HRLGG; n = 5) stool induced an increase in the proportion of a. Treg cells and b. IL10, compared with high risk for asthma placebo (HRP; n = 5) or healthy (HC; n = 5) participants. At 12 months of age, 6 months following cessation of LGG supplementation, no difference in the proportion of c. Treg cells or d. IL10 expression was observed between the three groups. Linear mixed effects (LME) adjusted for blood-donor was used to test for between group differences
