Fig. 6 | Nature Communications

Fig. 6

From: PARP1 and PARP2 stabilise replication forks at base excision repair intermediates through Fbh1-dependent Rad51 regulation

Fig. 6

PARP1 and PARP2 contribute to the resolution of DNA damage caused by base alkylation through two mechanisms. Alkylated bases are processed into DNA single-strand breaks during BER and their repair is accelerated by XRCC1, PARP1 and PARP2. During S-phase, active replication forks can collide with unrepaired SSBs, or SSB repair intermediates, generating replication-associated DNA damage. This damage can be resolved through homologous recombination, which requires the formation of Rad51 filaments. PARP1 and PARP2 also contribute to this mechanism by antagonising the anti-recombinogenic activity of Fbh1, thus stabilising Rad51 nucleofilaments

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