Fig. 4

Amyotrophic lateral sclerosis patients show isolated degeneration of the corticospinal tract. a Means and standard deviations of FA and RD values are shown for ALS patients (blue) and control subjects (red). Individual patients are displayed as light blue lines for the CST. At the level of the cerebral peduncle, patients differ from controls by more than 1 standard deviation (black arrow). No other tracts show this large effect. b Means and standard errors are shown for ALS and control subjects to indicate regions of significant group differences. Group differences are relatively specific to the CST (see Figure5_ALS.m and https://YeatmanLab.github.io/Sarica_2017/)