Table 1 Coordination and fitting parameters 17O relaxation profiles

From: Chiral DOTA chelators as an improved platform for biomedical imaging and therapy applications

 

[GdL1]−

[GdL2A]−

[GdL2B]−

[Gd(R)L2A]−

[Gd(R)L2B]−

[GdL5]−

[GdDOTA]−43, 59

Gd-DOTMA43

Gd-NB-DOTA60

Gd-NB-DOTMA(S-SSSS)44

Gd-NB-DOTMA(S-RRR)44

Coordination

Mix

SAP

TSAP

SAP

TSAP

SAP

SAP

TSAP

SAP

TSAP

Mix

SAP

TSAP

τM310K (ns)

13 ± 0.4

6.6 ± 0.4

1.1 ± 0.1

8.1 ± 0.4

2.9 ± 0.1

16 ± 0.8

141

27

156

26

111

77

9.4

ΔH‡ (kJ mol-1)

16 ± 1.4

43 ± 2.0

29 ±3 .2

33 ± 2.1

12 ± 1.7

18 ± 2.5

58.1 ± 2.5

41.9 ± 3.1

53.4 ± 2.9

40.3 ± 2.2

35.5

26.4

27.7

  1. The mean residence time of the water co-ligand at 310 K (τM310K) and enthalpy change of activation of water exchange (ΔH‡) for Gd(III) complexes. Each measurement was repeated three times and an average value is given. Error values refer to statistical data fitting analysis (n = 3; s.e.m.)
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