Fig. 5 | Nature Communications

Fig. 5

From: Phosphorylation of conserved phosphoinositide binding pocket regulates sorting nexin membrane targeting

Fig. 5

Mutation of the conserved PIP-stop residue Ser72 modulates membrane association. a The conservation of SNX3 residues is colored on the ribbon structure as indicated in the inset. The proximal Ser72 and PI3P pocket positions are indicated. b The binding affinities of wild type SNX3 and S72A and S72E mutants for PI3P-containing bilayers were measured by SPR, and show that the S72A mutation preserved activity whereas the S72E mutation abrogates binding

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