Table 3 Affinities of SNX3 for lipid molecules and mixed micelles

From: Phosphorylation of conserved phosphoinositide binding pocket regulates sorting nexin membrane targeting

Ligand

Kd (μM)a

Ins(1,3)P2

169.6 ± 34.1

c4-PI3P

158.9 ± 36.1

DHPC + CHAPS

>2000

DH7PC + CHAPS

>2000

DPC + CHAPS + Ins(1,3)P2

57.4 ± 16.4

DPC + CHAPS + c4-PI3P

n.d. (slow exchange)

DHPC + CHAPS + c4-PI3P

n.d. (slow exchange)

DPC + CHAPS + c8-PI3P

n.d. (slow exchange)

  1. aValues determined by NMR chemical shift perturbations
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