Table 1 Overview of cell types immortalized in this study

Human chondrocytes

e-hChon-1

ID2, FOS, TAg, ID3, E7, E6, Bmi1, PymT, Core, Klf4, ID1, MYC, Nanog, EZH2

p

e-hChon-2

ID2, FOS, ID3, E7, Core, Klf4, ID1, Lmo2, Nanog, SOX2, EZH2

p

e-hChon-3

ID2, ID3, E6, Bcl2, Core, Myc, Nanog, Sox2

p

e-hChon-4

Fos, Nanog, EZH2

p

0/3

Human dermal fibroblasts

e-hDFib1

Myb, E7, HoxA9, Core, Myc

p

0/3

e-hDFib2

E7, MYC

p

e-hDFib3

ID2, FOS, ID3, E7, Core, ID1, MYC

p

Human foreskin fibroblasts

e-hFib-1

RhoA, EZH2

p

e-hFib-2

Nanog

p

0/3

e-hFib-3

ID3, E7, Core, ID1, MYC, Yap1, Nanog, EZH2, Rex

p

Human lymphatic endothelial cells (dermis)

e-hLEC-1

ID2, FOS, ID3, Core, Klf4, ID1, MYC

p

e-hLEC-2

MYC, ID1, ID2

p

Human microvascular endothelial cells (dermis)

e-hMEC-1

ID2, Fos, TAg, ID3, E7, HoxA9, ID1, MYC, Nanog, Sox2, EZH2, Gli1

p

e-hMEC-2

ID2, FOS, ID3, BCL2

p

e-hMEC-3

ID2, FOS, ID3, HOXA9, ID1, Nanog, EZH2

p

Human osteoblast

e-hOB-1

ID2, FOS, TAg, E7, MYC

p

e-hOB-2

Fos, TAg, Bcl2, MYC, Nanog, EZH2, Rex

p

2/3

e-hOB-3

ID2, TAg, E7, Myc

p

e-hOB-4

FOS, ßCAT, TAg, E7, ID1, MYC

p

Human bone marrow stroma cells

e-hStr-1

ID2, FOS, ID3, E7, E6, Core, ID1, Lmo2, Yap1, Nanog, SOX2, EZH2

p

0/3

e-hStr-2

ID2, MYB, ID3, E7, E6, MYC, Yap1, Nanog, EZH2

p

e-hStr-3

ID2, Fos, E7, ID1, Lmo2, Yap1, Nanog, Sox2

p

0/3

e-hStr-4

ID2, E7, MYC, Nanog, SOX2, EZH2

p

e-hStr-5

E7, E6, Bmi1, ID1, MYC, Lmo2, Yap1, Nanog, SOX2

p

Human endothelial cells (umbilical cord)

e-hUVEC-1

ID2, FOS, MYB, ID3, E7, ID1, MYC, Nanog, EZH2, Rex

p

e-hUVEC-2

MYC, ID1, ID2

p

0/6

e-hUVEC-3

Fos, Id3, Bmi1, Yap1, Nanog

p

e-hUVEC-4

SUZ12; ID4, Rex

p

e-hUVEC-5

ID2, FOS, ID3, E6, HoxA9, Core, Klf4, ID1, MYC

p

e-hUVEC-6

ID2, FOS, ID1, MYC

p

e-hUVEC-7

MYC, ID1, ID2

p

e-hUVEC-8

MYC, ID1, FOS

p

e-hUVEC-9

MYC, ID2, FOS

p

e-hUVEC-10

MYC, ID1, ID2

p

Murine hepatocytes

e-mHepA

TAg, KLF4, ID3, Core

c

0/3

0/11

e-mHepB

TAg, ID3

p

3/3

3/3

e-mHepC

KLF4

p

0/3

0/6