Table 1 Biological data. Scoring of active compounds from SAR screening

From: Scalable total synthesis and comprehensive structure–activity relationship studies of the phytotoxin coronatine

 

Post-emergence

Pre-emergence

Compound

AMARE

LOLPE

STEME

DIGSA

Symptom

AMARE

LOLPE

STEME

DIGSA

Symptom

(+)-1

90

60

NT

90

ST/DS

80

90

NT

100

ST/DS

(±)-1

40

0

50

60

NC/ST

70

40

70

80

NC/ST

(±)-2

0

0

0

0

0

0

0

0

(±)-3

0

0

0

0

0

0

0

0

16

0

0

0

0

ST

0

0

50

0

ST

21

0

0

70

20

NC/ST

0

0

0

0

NC/ST

32*

0

0

0

0

ST

50

0

80

0

ST

35

0

0

0

0

ST

20

0

50

50

ST

36*

50

40

0

60

ST

40

30

50

50

ST

38a*

70

70

70

80

NC/ST

80

60

80

80

NC/ST

41a

30

20

30

60

GI/ST

0

20

80

0

GI/ST

43a*

30

10

0

50

GI/ST

30

60

40

80

GI/ST

45a

30

20

10

100

NC/ST

20

20

20

40

NC/ST

39b*

20

0

40

0

ST

30

40

70

0

ST

  1. In initial greenhouse screening (GH1), compounds are assessed for pre- and post-emergence activity against four weed species, and scored visually for % phytotoxicity (0–100, where 100 is complete control of the target and 0 is no control). Key compounds are designated with asterisks
  2. AMARE Amaranthus retroflexus, LOLPE Lolium perenne, STEME Stellaria media, DIGSA Digitaria sanguinalis, DS desiccation, GI germination inhibition, NC necrosis, NT not tested, ST stunting