Fig. 10 | Nature Communications

Fig. 10

From: RNA cytosine methylation and methyltransferases mediate chromatin organization and 5-azacytidine response and resistance in leukaemia

Fig. 10

Increased expression of hnRNPK, NSUN1 and BRD4 as well as their co-localization with active RNA-pol-II in 5-AZA-resistant AML/MDS specimens. a Visualization and quantitative measurement of co-localization of NSUN1 and RNA-pol-II CTD-S2P in 5-AZA-sensitive and 5-AZA-resistant clinical AML/MDS bone marrow specimens by PL-RCA. b Visualization and quantitative measurement of co-localization of NSUN1 and BRD4 in 5-AZA-sensitive and 5-AZA-resistant clinical AML/MDS bone marrow specimens by PL-RCA. c Morphological and immunohistochemical studies of the expression of CD34, hnRNPK, NSUN1 and BRD4 in the bone marrow cells from normal controls, cytogenetically normal MDS/refractory cytopenia with multilineage dysplasia (RCMD), and AML, n = 10 for each group, with an Olympus BX43 microscope at ×400 magnification. d STED confocal microscopic analysis of the expression and subcellular localization of hnRNPK and RNA-pol-II CTD-S2P in normal and AML bone marrows

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