Fig. 4 | Nature Communications

Fig. 4

From: Scalable synthesis enabling multilevel bio-evaluations of natural products for discovery of lead compounds

Fig. 4

Total Syntheses of Isodon diterpenoids. With (±)−11 as the common intermediate, the total syntheses of (±)-eriocalyxin B (1), (±)-neolaxiflorin L (2) and (±)-xerophilusin I (3) were achieved via a conformation and H-bond guided redox–relay strategy in 7–10 steps with 19–26% overall yields. The synthetic route can be operated in hundred-milligram-to-decagram scales

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