Fig. 3 | Nature Communications

Fig. 3

From: USP15-dependent lysosomal pathway controls p53-R175H turnover in ovarian cancer cells

Fig. 3

MCB-613 causes nuclear export of p53-R175H protein. a–d MCB-613 caused a rapid export of p53-R175H (TYK-Nu cells) protein but not b p53-WT (ALST cells) or other GOF mutp53 c p53-R273H (OVCA420 cells), and d p53-R248Q (OVCAR3 cells). e, f Upon MCB-613 treatment, p53-R175H (green) co-localizes with e lysosomes (red; lysotracker) and f endoplasmic reticulum (red; α-calnexin) in TYK-Nu cells

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