Table 1 Summary of the in vitro tests and transfection efficiency in cells using different vector materials
Non-viral vectors | Saturated concentration of ssDNA (wt%)a | Survived portion in serum (%) | Release efficiency (%) | Efficiency in RAW264.7 (%) | Efficiency in THP-1 (%) | Efficiency in CD4+ T (%) | Efficiency in B cell (%) |
|---|---|---|---|---|---|---|---|
Ni-IRMOF-74-II | 6.9 | 95 | 55 | 81 | 2 | 61 | 68 |
Ni-IRMOF-74-III | 6.9 | 95 | 25 | 80 | 30 | 92 | 89 |
UiO-66 | 1.5 | 7 | 0 | NA | NA | NA | NA |
UiO-67 | 1.3 | 7 | 0 | 14 | 7 | NA | NA |
MIL-101 | 5.8 | 3 | 0 | 12 | 7 | NA | NA |
SBA-15 | 2.6 | 7 | 33 | NA | NA | NA | NA |
Lipo | 0.02 | 88 | 0 | 30 | 6 | 58 | 73 |
Neofect | 0.1 | 100 | 24 | 40 | 11 | 50 | 75 |
