Fig. 5 | Nature Communications

Fig. 5

From: The ng_ζ1 toxin of the gonococcal epsilon/zeta toxin/antitoxin system drains precursors for cell wall synthesis

Fig. 5

ngζ_1 drains precursors from peptidoglycan synthesis at multiple stages. Under normal conditions cytosolic levels of UNAM regulate peptidoglycan synthesis by a negative feedback loop inhibiting MurA. In contrast, once ngζ_1 becomes active, MurA, MurB, and MurC are depleted from their substrates. All phosphorylated precursors are dead-end metabolites; however, none of them seems to directly inhibit any enzyme of early peptidoglycan synthesis

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