Fig. 2

Univariate analysis of the left HC long axis ROIs. a Depiction of the three hippocampal ROIs: aHC (Y = −4 to −18) = light green, mHC (Y = −19 to −29) = green, pHC (Y = −30 to −40) = dark green. Visualizations of the anatomical masks are superimposed on a sagittal section of a template image. b FIR time courses over the first 15 s (7TRs) for all picture types combined. Statistical comparisons were calculated for the peak response (average of the 5 s and 7.5 s time points). The activity in the 28 d group compared to the 1 d group decreased in the aHC (main effect Group: F_(1,46) = 15.46, p = 0.0003, generalized η² = 0.1546, n = 48) and mHC (F_(1,46) = 9.24, p = 0.0038, generalized η² = 0.0999, n = 48). There was no difference between the groups in the pHC (F(1,46) = 1.70, p = 0.1986, generalized η² = 0.0230, n = 48). For effects of Picture Type and Emotion see Supplementary Fig. 6. c Correlations of the percentage of FA to related items with the contrast value for related pictures vs baseline: across groups, there was a negative correlation in the aHC and mHC, but not in the pHC. Calculating the correlations separately for each group showed a significant correlation in the aHC for the 1 d group (t(22) = −2.37, p = 0.027, Pearson’s r = −0.45, n = 24) and a trend in the 28 d group (t(22) = −1.62, p = 0.121, Pearson’s r = -0.37, n = 24), while correlations for each group separately were not significant in the mHC and pHC. d Correlations of the Confidence Score with the contrast value for old pictures vs baseline: across groups, there was a positive correlation in the aHC and mHC, but not in the pHC. Note, however, that none of the correlations with the Confidence Score were significant when calculating them separately for each group. For analysis of the right HC long axis ROIs see Supplementary Fig. 7. *p < 0.05, **p < 0.001, all error bars are SEM