Fig. 2
Epitopes and breadth of broad and narrow antibodies targeting HA. a Crystal structures of the broad antibodies and sites of escape mutations selected by the narrow ones superimposed on the structure of the HA trimer (PDB 1RVX77). S139/1 (PDB 4GMS27) targets residues in the receptor-binding pocket; C179 (PDB 4HLZ49) and FI6v3 (PDB 3ZTN26) target the stalk. The sites of escape mutations for H17-L19, H17-L10, and H17-L7 are those mapped by Doud et al47. b A phylogenetic tree of HA subtypes. Circles (broad antibodies) and squares (narrow antibodies) denote reported antibody binding or neutralization activity against that subtype. Not all antibodies have been tested against all subtypes
