Fig. 5 | Nature Communications

Fig. 5

From: The RNA-binding protein ARPP21 controls dendritic branching by functionally opposing the miRNA it hosts

Fig. 5

ARPP21 and miR-128 bind an overlapping set of target mRNAs with related functions. a Venn diagram of conserved TargetScan 7.1 miR-128 target mRNAs, and ARPP21 iCLIP substrate mRNAs. b 7mer-A1 seed match occurrence per 3′UTR of ARPP21 targets for several conserved miRNAs. c Number of occurrences of miR-128 seed matches and poly-uridine (poly-U) 7mers per 3′UTR among ARPP21-bound and ARPP21-unbound transcripts. Both motifs are significantly enriched in 3′UTRs of ARPP21 target mRNAs. Welch two-sample t-test, ***p < 2.2 × 10−16. d miR-128 and poly-U 7mer occurrence normalized per kilobase of 3′UTR comparing ARPP21 target and non-target transcripts. ***p < 2.2 × 10−16

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