Fig. 2
From: Progress and challenges towards targeted delivery of cancer therapeutics
The impact of nano–bio interactions on the systemically administrated NCs. a During systemic circulation, targeted NCs get coated with serum proteins and opsonins, which impacts the targeting efficiency and many other properties of NCs, including b particle size, c pharmacokinetics, d release profiles, e tissue penetration, f cellular uptake and intrecellular trafficking and g biodistribution (ID injected dose)
