Fig. 3
From: Increased formate overflow is a hallmark of oxidative cancer
Baseline rates of serine catabolism to formate in murine tissues. a Diagram illustrating the 13C-methanol tracing and in vivo metabolic flux analysis protocol. b–d Serine, NAD+/NADH and SCI for brain, liver and spleen samples from mice 24 h post 13C–MeOH injection. e Relative rate of serine catabolism to formate (SCF) of brain, liver and spleen as estimated from the 13C–MeOH tracing protocol. f De novo purine synthesis rate in brain, liver and spleen inferred from the 13C enrichment of purines. Results were obtained from three mice (n = 3). Error bars denote s.e.m.. p-values are calculated using an unpaired t-test with Welch’s correction
