Fig. 6
From: Increased formate overflow is a hallmark of oxidative cancer
Formate overflow promotes cancer cell invasion in GBM. a Cartoon illustrating the experimental setup to analyze cancer cell invasion using coated Boyden chambers. b–d Addition of extracellular sodium formate increases invasiveness in a concentration dependent manner in b U87, c LN229 and, d NCH601 cells. e, f Reduced invasiveness by MTHFD1L knockdown can be rescued with extracellular formate in e LN229 and f NCH601 cells. Each dot indicates one independent experiment (n = 3). Error bars indicate s.e.m. p-values are calculated using an unpaired t-test with Welch’s correction
