Fig. 4
Cellular vaccine supports effective boosting and re-boosting. a Schematic representation of experimental protocol assessing cellular vaccine efficacy. b i.p. booster vaccines were administered to mice receiving transfer of 1 × 107 pT-effluc-thy1.1-modified CD8+ T cells. The blue timeline arrow indicates the days after ACT. Red arrows indicate i.p. cellular vaccine administration on days 28, 58, and 298. A representative image (a–c) corresponds to the blue arrow timeline (N = 5). c Effective boosting by i.p. T-cell vaccine was observed 300 days (image, c, shown are four of the five mice) after ACT of 1 × 107 pT-effluc-thy1.1-modified cells co-administered with the i.v. OVA + OT-1 T-cell vaccine
