Fig. 7 | Nature Communications

Fig. 7

From: Transposon-modified antigen-specific T lymphocytes for sustained therapeutic protein delivery in vivo

Fig. 7

Modified EBV-specific T lymphocytes produce EPO and retain target specificity. a Genome modification of EBV-CTLs with pT-tight-hEPO results in tight regulation of EPO expression (N = 3 ± SEM). b pT-tight-hEPO-modified EBV-CTLs lyse target cells with similar efficiency as unmodified EBV-CTLs, indicating that genome-modified EBV-CTLs retain target specificity. Untransfected EBV-CTLs (UT-EBV-CTLs) lysed autologous LCLs (auto-LCLs) as did EBV-CTLs transfected with pT-tight-hEPO (ihEPO-EBV-CTLs) with auto-LCLs. However, ihEPO-EBV-CTLs did not lyse allologous LCLs (allo-LCLs)

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