Fig. 3 | Nature Communications

Fig. 3

From: Cooperative STAT/NF-κB signaling regulates lymphoma metabolic reprogramming and aberrant GOT2 expression

Fig. 3

Proliferation of P493-6 and B-cell lymphoma cells requires transaminase activity. a Inhibition of cell doubling of IL10 + CpG-stimulated P493-6 MYClow and P493-6 MYChigh cells after 24 h of treatment with CB-839 or AOA. b Inhibition of cell doubling of the B-cell lymphoma cell lines CA-46, OCI-Ly3, and L-428 using CB-839 or AOA treatment for 24 h. c Intracellular amino acid abundance in IL10 + CpG-stimulated MYClow and MYChigh cells 24 h after AOA treatment and stimulation. For each amino acid data were normalized relative to the corresponding values of DMSO-treated cells. For all plots, error bars represent mean ± SD of three independent experiments and results from Bonferroni post hoc tests on a one-way ANOVA are given (*p < 0.05, **p < 0.01, ***p < 0.001)

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