Fig. 6
From: Gene expression links functional networks across cortex and striatum
Differential expression across cortical and striatal networks is consistent within independent human datasets. a RNAseq data from 111 putamen, 130 NAcc, and 144 caudate tissue samples were obtained from the Genotype-Tissue Expression (GTEx) project. GTEx samples from the NAcc correspond to the limbic aspect of striatum in the AHBA dataset. Across all genes, differential expression (i.e., log2 fold change) in GTEx NAcc, relative to caudate and putamen, co-varied with differential expression in AHBA limbic striatum (r = 0.74, p ≤ 0.001). b RNAseq data for 8 adult donors sampling 11 cortical brain regions were obtained from the Brainspan atlas. Across all genes, fold change in Brainspan limbic cortex (i.e., OFC, ACC, ITC) correlated with fold change in the AHBA limbic cortex (r = 0.69, p ≤ 0.001). c Gene-wise fold change in Brainspan somato/motor cortex (i.e., M1C, S1C, A1C) correlated with fold change in the AHBA somato/motor cortex, r = 0.51, p ≤ 0.001. Gray denotes genes that are not positively differentially expressed. d Somatostatin receptor 1 (SSTR1) was expressed most within limbic cortex and striatum of both AHBA and replication data. e Parvalbumin (PVALB) was expressed most within somato/motor cortex and striatum of both AHBA and replication data. Error bars reflect ± 1 SEM
