Table 2 Pathways with a significant effect (Pcorrected < 0.05) on broad depression following multiple testing correction identified through gene-set enrichment analysis

From: Genome-wide association study of depression phenotypes in UK Biobank identifies variants in excitatory synaptic pathways

Phenotype

Pathway

Number of genes

Beta (St. Err.)

P-value

PCorrected

Broad depression

GO_EXCITATORY_SYNAPSE

182

0.346 (0.069)

2.38 × 10−7

0.004

GO_MECHANOSENSORY_BEHAVIOR

11

1.390 (0.290)

7.99 × 10−7

0.009

GO_POSTSYNAPSE

352

0.241 (0.050)

8.26 × 10−7

0.009

GO_NEURON_SPINE

114

0.376 (0.085)

4.89 × 10−6

0.035

GO_DENDRITE

423

0.195 (0.045)

6.06 × 10−6

0.041

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