Fig. 8 | Nature Communications

Fig. 8

From: The basic helix-loop-helix transcription factor SHARP1 is an oncogenic driver in MLL-AF6 acute myelogenous leukemia

Fig. 8

Oncogenic role for SHARP1 in MLL-AF6 AML MLL-AF6 protein binds to and activates the SHARP1 gene in a DOT1L-dependent manner. Upregulated SHARP1 binds to E-box motifs in active chromatin, and also interacts with MLL-AF6 to regulate a subset of genes critical for leukemogenicity. This unique transcriptional machinery contributes to the maintenance of MLL-AF6 AML leukemic stem cells

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