Fig. 4

Diurnal transcriptome of the mouse liver. a Distribution of diurnal rhythmic transcripts. b Hierarchical clustering of the cycling transcripts ordered by the time of the oscillation. Values for each transcript at all analyzed samples (columns) are color code based on the intensities, low (blue) and high (yellow) z-scored normalized FPKM. The upper white to black bar indicates the 2 days’ cycle. Daytime is shown in white, while nighttime is shown in black. Temporal abundance of transcripts of Bmal1, Dbp, Per1, and Bhlhe40 in 2 consecutive cycles. X axis represents the sampled time points; Y axis represents z-scored FPKM. c Area graph shows the normalized abundance of transcripts that peaked in different time of the day (red: daytime, green: nighttime). Bar plots shows the GO terms enriched by diurnal peaked transcripts (black), and GO terms enriched by diurnal rhythmic transcripts (JTK_CYCLE, p < 0.1) (red). d The hierarchical pyramid shows the number of TFs, diurnal rhythmic TFs, transcriptome nominated DR-TFs. The Rose diagram shows the number of transcriptome nominated DR-TFs of each time phase, TFs were colored based on their peaked phase, (TP1 shows in yellow, TP2 shows in red, TP3 shows in green, TP4 shows in blue). e The regulation network of DR-TFs to their TGs (target genes), TFs were colored based on their peak phase