Fig. 4 | Nature Communications

Fig. 4

From: Pharmacodynamics of mutant-IDH1 inhibitors in glioma patients probed by in vivo 3D MRS imaging of 2-hydroxyglutarate

Fig. 4

Relation between the treatment induced changes of 2HG and other metabolic and imaging biomarkers. Linear model fitting has been employed to investigate the relationship between the changes: a 2HG and GSH; b 2HG and Glx; c ratio of 2HG/Glx and ADC. A significant inverse correlation was found between changes of 2HG/Glx ratio and changes of ADC after 1 week of treatment with IDH305

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