Fig. 4

SEC-MALS analysis of LGI1–ADAM22 ECD complex. SEC-MALS analyses of LGI1^WT–ADAM22 ECD (purple), LGI1^R474Q–ADAM22 ECD (blue), and LGI1 EPTP–ADAM22 ECD (orange) in 20 mM Tris-HCl (pH 7.5) buffer containing 150 mM, 300 mM, or 500 mM NaCl. Chromatograms and determined molar masses are shown