Fig. 6
The expression of BARD1 and BRCA1 are increased in metastatic breast cancer and associated with poor prognosis in ER+ breast cancer patients received radiotherapy. a, b Representative pictures (a) and quantification (b) of IHC staining of BARD1, BRCA1, and p-AKT in paired primary and metastatic breast cancer tissues. c, d Correlation analysis of p-AKT expression with BARD1 (c) or BRCA1 (d) expression in primary and metastatic breast cancer samples. e Overall survival of breast cancer patients in Curtis data set with or without radiotherapy whose tumors had high or low BARD1/BRCA1 expression. In b, data show means ± s.d. (n = 27) *p < 0.05; **p < 0.01; ***p < 0.001 compared with that in primary breast cancer by Student’s t test. Scale bar indicated 400 µm
