Fig. 2

CEUS non invasively detects changes in the pancreas blood flow dynamics following STZ-induced β-cell injury. a Ad-libidum blood glucose concentrations of female C57BL/6 mice injected with 70 mg/kg STZ or buffer (control) before (baseline) and 2 weeks post treatment (2w post). b Reperfusion rate measured in mice in a treated with 70 mg/kg STZ or control before and 2 weeks post treatment. c Data in b showing changes in individual mice for reperfusion rate. d As in b measuring reperfusion amplitude. e Glucose tolerance tests from female C57BL/6 mice 2 weeks following treatment with buffer (control) or 50 mg/kg STZ. f Reperfusion rate measured in mice treated as in e with 50 mg/kg STZ or control before and 2 weeks post treatment. g Data in f showing the changes in individual mice for reperfusion rate. h As in f measuring reperfusion amplitude. Error bars represent s.e.m. * p < 0.05 comparing groups indicated (paired t-test for data in c, g; ANOVA for data in a, b, d, f, h). Data in a–d represents n = 6 STZ-treated (n = 9 at baseline for b, d) and n = 5 control mice (n = 7 at baseline for b, d); data in e represents n = 8 STZ-treated and n = 3 control; data in f–h represents n = 8 STZ-treated and n = 6 control mice