Fig. 2 | Nature Communications

Fig. 2

From: Canonical PI3Kγ signaling in myeloid cells restricts Trypanosoma cruzi infection and dampens chagasic myocarditis

Fig. 2

PI3Kγ signaling in hematopoietic cells is essential for mouse resistance to T. cruzi infection. a–c Body weight (a) and survival rate of C57BL/6 WT (n = 10) and Pik3cg−/− (n = 10) (b) or Pik3cgKD/KD (n = 10) (c) mice infected with 103 trypomastigote forms of T. cruzi Y strain. d, e Blood parasitemia of WT and Pik3cg−/− (d) or Pik3cgKD/KD (e) mice infected with 103 trypomastigote forms of T. cruzi Y strain. f Survival rate of chimera mice infected with 500 trypomastigote forms of T. cruzi Y strain. *P < 0.05, ***P < 0.001, and ns = no statistical significance (unpaired Student’s t-test in a, d, e and Mantel–Cox log-rank test in b, c, f). Data are representative of two (f) of three (a–e) independent experiments (mean ± s.e.m in a, d, e)

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