Fig. 3
PI3Kγ is important for the heart function of T. cruzi-infected mice. a, b Serum CK-MB level of WT (n = 4), Pik3cg−/− (n = 4) (a) and Pik3cgKD/KD (n = 7) (b) non-infected mice or 18 days post infection with 103 trypomastigote forms of T. cruzi Y strain. c Representative images of echocardiography in WT (n = 6) and Pik3cg−/− (n = 6) non-infected mice or 18 days after infection with T. cruzi. Red arrows indicate diastolic ventricular diameter and yellow arrow indicates diastolic ventricular wall thickness. d–g Diastolic left ventricle diameter (d), diastolic left ventricular posterior wall thickness (e), ejection fraction (f), and cardiac output (g) of WT (n = 6) and Pik3cg−/− (n = 6) non-infected mice or 18 days after infection with 103 trypomastigote forms of T. cruzi Y strain. *P < 0.05 and **P < 0.01 relative to WT-infected mice and #P < 0.05 and ##P < 0.01 relative to non-infected group (one-way ANOVA with Tukey’s post hoc test in a, b, d–g). Data are representative of two independent experiments (mean ± s.e.m in a, b, d–g)
