Fig. 8
From: Reduced oxidative capacity in macrophages results in systemic insulin resistance
GDF15 reverses insulin resistance caused by reduced oxidative function. a Body weight changes in MacWT or MacHO mice fed a HFD for 12 weeks and intraperitoneally injected with rGDF15 (300 μg/kg) every other day for 2 weeks (n = 5 per group). b IPGTT performed after rGDF15 treatment. c HOMA-IR of HFD-fed MacWT and MacHO mice after treatment with rGDF15. d, e FACS analysis of macrophages (CD45+/F4/80+/CD11b+) and M1 (CD11c+/CD206-) and M2 (CD11c-/CD206+) macrophages infiltrated into eWAT. f Body weight changes in ob/+ and ob/ob mice treated with rGDF15 (300 μg/kg) for 2 weeks (n = 5 per group). g HOMA-IR of ob/+ and ob/ob mice after GDF15 treatment. h, i FACS analysis of macrophages (CD45+/F4/80+/CD11b+) and M1 (CD11c+/CD206-) and M2 (CD11c-/CD206+) macrophages infiltrated into eWAT of ob/+ and ob/ob mice. Data represent means ± SEM and are representative of three independent experiments. *p < 0.05 (two-tailed Student’s t-test)
