Fig. 4
From: Epigenetic landscape influences the liver cancer genome architecture
Mutational signature analysis of 266 hepatocellular carcinomas. a Eight mutational signatures identified from active or inactive chromatin states of 266 HCCs. The y-axis indicates the frequency of each of the 96 substitution patterns. The stability of the signature and the most similar COSMIC signature are shown in Supplementary Table 4. b Contribution of the eight mutational signatures to each tumor in active and inactive chromatin states. The y-axis indicates the number or the contribution of mutations in each signature. HBV: hepatitis B virus-related HCCs, HCV: hepatitis C virus-related HCCs, NBNC: HCCs without HBV or HCV infection. The differences in the odds ratios among viral features are shown in Supplementary Table 5. c Odds ratio of the contribution of the signature in active and inactive chromatin
