Fig. 6
From: Regulation of Yki/Yap subcellular localization and Hpo signaling by a nuclear kinase PRP4K
Model for how PRP4K regulates Hpo signaling. PRP4K phosphorylates Yki/Yap in the nucleus to promote its cytoplasmic translocation whereas the Hpo/Mst1/2-Wts/Lats1/2 kinase cassette phosphorylates Yki/Yap to promote its binding to 14-3-3, resulting in sequestration of Yki/Yap in the cytoplasm
