Fig. 5
From: Chemokines cooperate with TNF to provide protective anti-viral immunity and to enhance inflammation
Impaired virus spread in the absence of ECTV CrmD. Graphs show viral titres at 3, 7 and 11 dpi in spleen (a) and liver (b) of BALB/c mice infected with 1000 PFU per animal of the indicated viruses. Data are mean log +/− SEM of groups of five animals for each condition. Note that mice infected with ECTV or ECTVRevCrmD did not survive up to 11 dpi. Left hind foot anti-poxvirus staining (c–e) or anti-CrmD staining (f–h) of zinc-fixed footpad sections of representative BALB/c mice infected with 1000 PFU of ECTVRevCrmD (c, f), ECTVΔCrmD (d, g) or ECTVRevCRD (e, h) at 7 dpi. H&E staining of spleen (i–k) or liver (l–n) sections of representative mice infected with 1000 PFU of ECTVRevCrmD (i, l), ECTVΔCrmD (j, m) or ECTVRevCRD (k, n) at 7 dpi. Insets show enlargement of selected areas to illustrate necrosis (l, n) and inflammatory infiltrate (m). Data are from one experiment representative of two independent experiments. Scale bar, 100 µm (c–k) and 40 µm (l–n)
