Table 1 Mortality rate determination of CrmD recombinant ECTVs in susceptible BALB/c mice
From: Chemokines cooperate with TNF to provide protective anti-viral immunity and to enhance inflammation
Dose (pfu) | ECTV | ECTV RevCrmD | ECTV ∆CrmD | ECTV RevCRD | ||||
|---|---|---|---|---|---|---|---|---|
Survivors | MTD | Survivors | MTD | Survivors | MTD | Survivors | MTD | |
10 | 4/10 | 10.0 (9–11) | 0/10 | 11.6 (9–21) | 10/10 | n.a. | 10/10 | n.a. |
10e2 | 0/5 | 11.8 (9–18) | 1/5 | 12.8 (10–11) | 5/5 | n.a. | 5/5 | n.a. |
10e3 | 0/5 | 10.4 (9–14) | 0/5 | 10.2 (9–13) | 5/5 | n.a. | 4/5 | 10 |
10e4 | n.d. | n.d. | 0/5 | 8.6 (8–10) | 5/5 | n.a. | 5/5 | n.a. |
10e5 | n.d. | n.d. | 0/5 | 9.6 (8–13) | 5/5 | n.a. | 3/5 | 9 (8–10) |
10e6 | n.d. | n.d. | n.d. | n.d. | 5/5 | n.a. | n.d. | n.d. |
10e7 | n.d. | n.d. | n.d. | n.d. | 4/5 | 14 | 1/5 | 12.5 (10–16) |
