Table 2 Histopathology of spleen and liver in recombinant ECTV-infected mice

From: Chemokines cooperate with TNF to provide protective anti-viral immunity and to enhance inflammation

 

3 dpi

7 dpi

11 dpi

 

Spleena

Livera / b

Spleena

Livera / b

Spleena

Livera / b

EV

−

− / −

+++

+ / +

n.a.

n.a.

EV RevCrmD

−

− / −

+++

+ / +

n.a.

n.a.

EV ∆CrmD

–

− / −

+

− / ++

+

− / ++

EV RevCRD

–

− / −

++

+ / +

+

− / ++

  1. Groups of five BALB/c mice were infected s.c. in the left hind footpad with the indicated viruses and sacrificed at different dpi. Spleen and liver were H&E-stained for histopathological analysis. Degree of necrosisa was semiquantitatively assessed using an arbitrary scale: − negative findings (0%); + slight (about 25% necrosis); ++ moderate (about 50% necrosis); +++ very intense (about 90–100% necrosis). Presence of inflammatory infiltrateb was evaluated in a minimum of 10 fields per liver slice section to obtain the mean value and it was scored as: − negative findings; + slight; ++ moderate; +++ very intense. n.a. not applicable
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