Fig. 3
From: Widespread intronic polyadenylation diversifies immune cell transcriptomes
Dynamic expression of IpA isoforms in immune cells. a Number of IpA isoforms with differential usage of IpA sites between NB from lymphoid tissue versus other immune cells (FDR-adjusted P < 0.05). b Heatmap showing IpA site usage of IpA isoforms with significantly different usage (FDR-adjusted P < 0.05) between NB derived from blood or lymphoid tissue (n = 720). Each row indicates an IpA isoform. c Enrichment of gene ontology terms for the genes shown in b. d Fold change of IpA isoform and full-length mRNA expression in blood versus lymphoid tissue-derived NB by TPM. All the genes that were tested for differential usage are shown (n = 892). If a gene had multiple IpA isoforms, then the one with the most significant differential IpA usage is shown. IpA isoforms with significantly different usage (FDR-adjusted P < 0.05) are highlighted in red (higher usage) or blue (lower usage). e Significant downregulation of full-length mRNAs in genes with significant IpA isoform expression (one-sided KS test, P < 10−5). Shown are genes highlighted in red from d
