Fig. 2
Classification of 159 signals and overlap by scan. The figure visualizes the classification of the 159 independent signals according to the position on the bWHR-bBMI-plane and their overlap by scan. a The Scatter plot shows the 159 variants on the bWHR-bBMI-plane, where bWHR and bBMI are the variant’s effect on WHR and BMI, respectively. Coloring indicates the four classes: BMI + WHR + (blue, nominal significant effects on BMI and WHR with consistent directions), BMIonly + (green, nominal significant effects on BMI only), WHRonly− (purple, nominal significant effects on WHR only) and BMI + WHR− (red, nominal significant effects on BMI and WHR with opposite directions). Symbols indicate a nominal significance purely for BMI (PBMI < 0.05, PWHR ≥ 0.05, upward triangle), purely for WHR (PBMI ≥ 0.05, PWHR < 0.05, downward triangle), or for both (PBMI < 0.05, PWHR < 0.05, stars). The dashed line indicates a null effect for WHRadjBMI (bWHRadjBMI = 0, estimated as bWHR = r*bBMI, with the correlation between BMI and WHR estimated from the population-based CoLaus study, r = 0.50). b The diagram shows the number of identified signals per class, illustrates the four classes in directed acyclic graphs and shows Venn diagrams per class to distinguish whether the signals were derived with genome-wide-significance by the BMI−, the WHR− or the WHRadjBMI-scan, or by multiple scans. The underlined numbers reflect the 53 genome-wide significant signals identified by the WHRadjBMI-scan
