Table 1 Results of class-specific enrichment analyses

From: A joint view on genetic variants for adiposity differentiates subtypes with distinct metabolic implications

		BMI + WHR+					BMIonly +					WHRonly−					BMI + WHR−
			Increasing		Decreasing			Increasing		Decreasing			Increasing		Decreasing			Increasing		Decreasing
Trait	N	n _Tested	n	P _Binomial	n	P _Binomial	n _Tested	n	P _Binomial	n	P _Binomial	n _Tested	n	P _Binomial	n	P _Binomial	n _Tested	n	P _Binomial	n	P _Binomial
Anthropometric traits
BMI	322,135	82	82	4.3E-132	0	1	25	25	8.9E-41	0	1	28	0	1	0	1	24	24	3.6E-39	0	1
WHR	212,216	82	82	4.3E-132	0	1	25	0	1	0	1	28	0	1	28	1.4E-45	24	0	1	24	3.6E-39
WC	232,083	82	82	4.3E-132	0	1	25	24	8.7E-38	0	1	28	0	1	14	1.1E-15	24	3	0.02	0	1
HIP	213,028	82	78	1.7E-119	0	1	25	25	8.9E-41	0	1	28	13	3.9E-14	0	1	24	23	3.3E-36	0	1
HT	253,239	82	17	2.0E-11	7	4.5E-03	25	6	2.9E-05	4	3.2E-03	28	4	4.9E-03	7	4.5E-06	24	7	1.5E-06	9	3.5E-09
WT	125,943	82	77	1.1E-116	0	1	25	24	8.7E-38	0	1	28	1	0.51	0	1	24	13	2.9E-15	0	1
Impedance measures
Body fat	114,178	80	72	1.1E-105	0	1	25	19	5.6E-26	1	0.47	28	4	4.9E-03	2	0.15	24	11	4.4E-12	0	1
Trunk fat	114,305	80	72	1.1E-105	0	1	25	17	5.2E-22	1	0.47	28	4	4.9E-03	2	0.15	24	10	1.4E-10	0	1
Leg fat	114,367	80	71	3.3E-103	0	1	25	20	4.3E-28	0	1	28	2	0.15	2	0.15	24	10	1.4E-10	0	1
Ectopic fat traits
VAT	18,312	82	21	9.6E-16	1	0.87	25	1	0.47	0	1	28	2	0.15	4	4.9E-03	24	1	0.46	1	0.46
SAT	18,206	82	24	2.8E-19	0	1	25	7	2.0E-06	0	1	28	3	0.03	0	1	24	6	2.2E-05	0	1
VAT/SAT	18,205	82	4	0.15	6	0.02	25	0	1	2	0.13	28	3	0.03	11	3.5E-11	24	0	1	11	4.4E-12
PAT	11,616	82	8	1.1E-03	0	1	25	1	0.47	0	1	28	1	0.51	0	1	24	1	0.46	7	1.5E-06
Cardio-metabolic traits and diseases
CAD	~185,000	81	15	1.6E-09	2	0.60	25	4	3.2E-03	3	0.02	28	2	0.15	5	5.9E-04	23	0	1	6	1.7E-05
MI	~170,000	81	9	2.0E-04	3	0.33	25	3	0.02	4	3.2E-03	28	0	1	2	0.15	23	0	1	5	2.3E-04
HDL-C	187,135	81	4	0.15	36	9.1E-36	25	2	0.13	6	2.9E-05	28	12	1.2E-12	2	0.15	24	15	9.8E-19	2	0.12
LDL-C	173,058	81	8	9.7E-04	4	0.15	25	2	0.13	2	0.13	28	1	0.51	9	1.7E-08	24	1	0.46	6	2.2E-05
TG	177,829	81	33	2.2E-31	2	0.60	25	4	3.2E-03	2	0.13	28	0	1	16	5.3E-19	24	0	1	15	9.8E-19
T2D	69,033	82	18	1.8E-12	1	0.87	25	3	0.02	2	0.13	28	0	1	4	4.9E-03	24	1	0.46	10	1.4E-10
FG	46,186	82	7	4.5E-03	2	0.61	25	1	0.47	2	0.13	28	0	1	1	0.51	24	0	1	2	0.12
FI	38,238	82	18	1.8E-12	0	1	25	3	0.02	1	0.47	28	0	1	3	0.03	24	0	1	9	3.5E-09

BMI: Body mass index; WHR: Waist-hip ratio; WC: Waist circumference; HIP: hip circumference; HT: Height; WT: Weight; VAT: Visceral adipose tissue volume; SAT: Subcutaneous adipose tissue volume; PAT: Pericardial adipose tissue volume; CAD: Coronary Artery Disease; MI: Myocardial Infarction; HDL-C: High-Density-Lipoprotein-Cholesterol; LDL-C: Low-Density-Lipoprotein-Cholesterol; TG: Triglycerides; T2D: Type 2 Diabetes; FG: Fasting Glucose; FI: Fasting Insulin
The table shows results from binomial tests that were conducted to test the variants of each class for enrichment of nominally significant increasing or decreasing effects on various traits including anthropometric traits, impedance fat measures, ectopic fat traits and cardio-metabolic traits, and disease. The table shows the number of variants tested (n_Tested), the number of variants with nominally significant trait-increasing or decreasing effects (n) and the respective binomial P value (P_Binomial). Bold binomial P values indicate significant enrichment (P_Binomial <0.05/168, Bonferroni-corrected for 168 binomial tests) of nominally significant trait-increasing or trait-decreasing effects on the respective lookup trait

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Table 1 Results of class-specific enrichment analyses

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