Fig. 3
From: Multi-omics profiling of younger Asian breast cancers reveals distinctive molecular signatures
Landscape of mutation signatures in SMC and TCGA. a Distribution of major mutation signatures across subtypes in SMC and TCGA. b Heatmap showing scores of major mutation signatures in SMC samples grouped by molecular subtypes. Sample-level mutation counts, age group, and menopausal status are illustrated by colored column labels. c Violin plots comparing signature 3 scores in SMC and TCGA samples binned by BRCA1/BRCA2 mutation and TP53 mutation statuses. Horizontal line indicates the median value. Violin plots of APOBEC signatures S2 (d) and S13 (e) vs. ERBB2 amplification status (amp: CN ≥ 6; WT: CN < 6) in SMC and TCGA; f Violin plots of HRD signature S3 vs. consensus molecular subtypes of SMC and TCGA. Student’s t test: ***p < 0.001; **p < 0.01; *p < 0.05
