Table 1 Loci associated with HR response to exercise

From: Thirty loci identified for heart rate response to exercise and recovery implicate autonomic nervous system

      

Discovery

Replication

Full

Locus

SNP

CHR

BP

EA

EAF

P

N

β

SE

P

N

β

SE

P

N

β

SE

RNF220*

rs272564

1

45012273

A

0.716

4.30E-05

38757

0.360

0.088

1.10E-08

25614

0.619

0.108

7.40E-12

65166

0.462

0.068

CCDC141

rs10497529

2

179839888

G

0.964

7.80E-07

39735

−1.049

0.212

9.10E-04

26261

−0.860

0.259

2.50E-09

66811

−0.968

0.162

SCN10A*

rs7433723

3

38784957

G

0.420

4.80E-06

39674

−0.364

0.080

7.40E-04

26221

−0.333

0.099

4.50E-08

66709

−0.335

0.061

SNCA1P*

rs4836027

5

121866990

T

0.693

5.70E-13

39214

0.617

0.086

1.20E-08

25917

0.599

0.105

9.90E-21

65935

0.613

0.066

PPIL1

rs236352

6

36817113

A

0.341

4.20E-06

39213

0.383

0.083

9.40E-05

25916

0.401

0.103

6.40E-10

65933

0.395

0.064

CAV2*

rs28495552

7

116113744

C

0.485

6.40E-06

39671

−0.355

0.079

1.70E-06

26219

−0.467

0.097

2.80E-11

66703

−0.403

0.061

RP1L1

rs58065122

8

10526186

G

0.582

6.60E-08

39187

−0.434

0.080

2.90E-03

25899

−0.294

0.099

3.90E-10

65889

−0.385

0.062

PAX2*

rs11190709

10

102552663

G

0.112

1.10E-04

39359

0.484

0.125

2.70E-08

26013

0.852

0.153

1.30E-11

66180

0.649

0.096

SOX5*

rs4246224

12

24784139

G

0.851

2.30E-10

39716

−0.702

0.111

5.40E-06

26248

−0.615

0.135

1.80E-14

66778

−0.649

0.085

SYT10*

rs1343676

12

33537387

T

0.494

2.20E-07

39537

−0.408

0.079

3.10E-05

26130

−0.404

0.097

1.50E-11

66477

−0.407

0.060

HMGA2

rs1480470

12

66412130

A

0.371

7.90E-06

39139

0.367

0.082

3.30E-03

25867

0.294

0.100

3.40E-08

65810

0.347

0.063

MCTP2*

rs12906962

15

95312071

T

0.680

5.60E-09

39222

0.496

0.085

1.10E-05

25922

0.461

0.105

3.50E-13

65949

0.475

0.065

TCF4

rs1125313

18

52859261

A

0.501

1.10E-05

39348

−0.349

0.079

1.30E-04

26005

−0.375

0.098

3.90E-09

66161

−0.359

0.061

POP4

rs7255293

19

30104198

A

0.580

9.60E-06

39405

0.354

0.080

3.40E-04

26043

0.352

0.098

3.20E-09

66257

0.363

0.061

  1. The locus name indicates the gene that is in the closest proximity to the most associated SNP
  2. Replicated SNPs are indicated in bold type
  3. * indicates the SNP is the same or in high LD (r2 > 0.8) with a SNP associated with the other HR response trait
  4. SNP single-nucleotide polymorphism, CHR Chromosome, BP Base pair Position, based on HG build 19, EA Effect allele, EAF Effect allele frequency from discovery data set, β Beta in beats per minute, SE Standard Error, N effective number of participants, P P-value
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