Fig. 9
From: Reversible glycosidic switch for secure delivery of molecular nanocargos
In vivo activity of 9AC-GW liposomes. a Concentrations of total 9AC-GW in plasma (free plus liposomal) at the indicated times after i.v. injection of 35 µmol kg−1 9AC-GW or 9AC-GW liposomes in mice. Error bars: SD, n = 3. b The concentration of 9AC in blood and MDA-MB-468 tumors after i.v. injection of 14.5 µmol kg−1 9AC-GW liposomes. Error bars: SD, n = 3. Statistical significance of differences in mean values are indicated: **p < 0.001 and ***p < 0.0001. The mean tumor volume (c), and mean body weight (d) of the treated mice bearing MDA-MB-468 tumors, injected i.v. four times at weekly intervals with TBS (control), 9AC (5.5 µmol kg−1), 9AC-GW (14.5 µmol kg−1) or 9AC-GW liposomes (14.5 µmol kg−1) are shown. Error bars: SD, n = 7 mice per group. Error bars: SD. Stars indicate significance; n.s non-significant, **p < 0.001 and ***p < 0.0001
