Fig. 6 | Nature Communications

Fig. 6

From: Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer

Fig. 6

Glycosylation on the NFL Env trimer and glycan fence around the CD4bs. a Glycosylation observed in the BG505 NFL.664 structure (with at least 0.8–1.0σ electron density). Glycans that are observed at less than 0.8σ have not been included for calculating observed moieties per sequon or modeled on the structure, but are included in parentheses in a. b Surface representation of BG505 NFL.664 (protomers 1–3 shown in shades of gray) with the PGV19 variable region (HC: yellow, LC: cyan) and the N-glycosylation observed in the crystal structure (N-acetyl-glucosamine in blue and mannose in green). The glycan fence is formed by N197, N363, N234, and N276 on the same protomer, along with N301, N295, and N262 on the adjacent protomer of the Env trimer that the CD4bs Abs have to circumnavigate to access their epitope. The zoomed-in panel illustrates the modeled interaction of Man9 at N301 with the heavy chain framework 1 (HFR1) of PGV19

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