Fig. 7 | Nature Communications

Fig. 7

From: Structure of a cleavage-independent HIV Env recapitulates the glycoprotein architecture of the native cleaved trimer

Fig. 7

Similarities and differences between VRC01-class lambda and kappa antibodies. a Top view in surface representation of the BG505 NFL.664 trimer in complex with PGV19 (crystal structure; HC: yellow, LC: cyan) and VRC03 (model based on EM map; HC: dark blue, LC: cyan) used in this study for crystallography and cryoEM experiments, respectively. b CD4bs interactions of PGV19 with BG505 NFL.664 as observed in the crystal structure. Inset: The lambda (PGV19) and kappa (VRC03) light chains both evolved a short CDRL3 to accommodate the N276 glycan, and CDRH1 is less than 11 residues to prevent clashes with the V5gp120 loop in Env (CDRHs: brown, CDRLs: purple). c Comparison of the CDR loop lengths of PGV19 and VRC0350 from HIV+ elite neutralizers and a naïve VRC01c-HuGL231 from an HIV-uninfected person

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