Fig. 3 | Nature Communications

Fig. 3

From: Enhanced efficacy of combined temozolomide and bromodomain inhibitor therapy for gliomas using targeted nanoparticles

Fig. 3

The bromodomain inhibitor JQ1 and temozolomide have additive effects in U87MG and GL261 glioma cells. a Representative immunofluorescence images of γH2AX DNA damage foci in U87MG and GL261 cells treated with 500 nM JQ1 and/or 150 μM TMZ for 72 h. Scale bar = 10 μm. b Cell viability plots demonstrating combinatorial effects of JQ1 and TMZ. Combinatorial index (C.I.) values determined using the Chou–Talalay method. Data presented as mean ± SEM of three separate experiments

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