Fig. 3
From: Deficiency of PRKD2 triggers hyperinsulinemia and metabolic disorders
PRKD2 K410X variation is shared by two hyperinsulinemic monkeys. a Sanger sequencing indicating one heterozygous nonsense variation in PRKD2 (K410X) exclusive to the two cases (950807, 960109). b As for the PRKD2 nonsense variation, the allele frequencies of the two alleles (WT, Mutant) were shown, according to the RNA-seq data in muscle and adipose tissue from a PRKD2 mutant monkey (950807). c Real-time PCR quantifications of the PRKD2 expression in skeletal muscle of WT and the PRKD2 mutant monkeys. d Western blots of PRKD2 protein expression in skeletal muscle (left) and adipose tissues (right) from control (black) and hyperinsulinemic (red) monkeys
