Fig. 3
IMs have the strongest correlation with CD14 and LUSC survival. a At top, the mRNA subtype of each sample is displayed (Classical: red, Basal: blue, Primitive: black, Secretory: green); CD14 expression levels sorting from left (lowest) to right (highest) for the corresponding samples are displayed below. Heat maps of the CD14 + populations that are associated with a statistically significant survival in LUSC are arranged by the most (IMs) to the least (MDSCs) statistically significant. CD14 is a marker both of IMs and MDSCs but is not shown in their heat maps, to avoid data redundancy. Note for the heat map figure legend: gray represents ‘null normalized values’ (NNV). b Scatter plot of overall survival results and CD14 scores for the 9 CD14 + immune cell types. Survival is represented with hazard ratio (HR) ± 95% confidence intervals. Values above 1 indicate worse survival based on cell type density. The CD14 score is the rank of the ratio between the average cell type density score of samples with high ( ≥ median) vs. low ( < median) CD14 levels. c Log-rank p-values of overall survival for the 9 CD14 + immune cell types (high vs. low cell density score). The red bars show statistically significant cases, while black bars are used when the statistical significance threshold of 0.05 is not reached
